| Protein name |
Lactoferrin |
| Host compatibility |
Komagatella phaffi (Pichia pastoris) |
| Yield |
3.5 g/L (Iglesias-Figueroa et al., 2016)
|
| Scale (in specific example) |
Lab scale in bioreactor (Iglesias-Figueroa et al., 2016)
|
| Biggest scale product has been develloped in this organism |
LF+ product from Turtletree likely on pilot or industrial scale
|
| Regulatory status in Europe |
Not allowed |
| Regulatory status in other parts of the world |
FDA GRAS approval in the US. Not allowed in Canada
|
| Companies producing this protein in this organism |
TurtleTree
|
| Extra/remark |
|
| Publications/references |
-
Iglesias-Figueroa, B., Valdiviezo-Godina, N., Siqueiros-Cendón, T., Sinagawa-García, S., Arévalo-Gallegos, S., & Rascón-Cruz, Q. (2016). High-Level Expression of Recombinant Bovine Lactoferrin in Pichia pastoris with Antimicrobial Activity. International Journal of Molecular Sciences, 17(6), 902. https://doi.org/10.3390/ijms17060902
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Vishwanath-Deutsch, R., Dallas, D. C., Besada-Lombana, P., Katz, L., Conze, D., Kruger, C., Clark, A. J., Peterson, R., & Malinczak, C. (2024). A review of the safety evidence on recombinant human lactoferrin for use as a food ingredient. Food and Chemical Toxicology, 189, 114727. https://doi.org/10.1016/j.fct.2024.114727
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Demir, R., Sarıtaş, S., Bechelany, M., & Karav, S. (2025). Lactoferrin: Properties and Potential Uses in the Food Industry. International Journal of Molecular Sciences, 26(4), 1404. https://doi.org/10.3390/ijms26041404
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Conesa, C., Calvo, M., & Sánchez, L. (2010). Recombinant human lactoferrin: A valuable protein for pharmaceutical products and functional foods. Biotechnology Advances, 28(6), 831–838. https://doi.org/10.1016/j.biotechadv.2010.07.002
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Wakabayashi, H., Yamauchi, K., & Abe, F. (2018). Quality control of commercial bovine lactoferrin. BioMetals, 31(3), 313–319. https://doi.org/10.1007/s10534-018-0098-2
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Zlatina, K., & Galuska, S. P. (2020). The N-glycans of lactoferrin: more than just a sweet decoration. Biochemistry and Cell Biology, 99(1), 117–127. https://doi.org/10.1139/bcb-2020-0106
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